Exposure to tricyclic antidepressant nortriptyline affects early-life stages of zebrafish (Danio rerio)
نویسندگان
چکیده
Psychiatric drugs are among the leading medications prescribed for humans, with their presence in aquatic environments raising concerns relating to potentially harmful effects on non-target organisms. Nortriptyline (NTP) is a selective serotonin-norepinephrine reuptake inhibitor antidepressant, widely used clinics and found environmental water matrices. In this study, we evaluated toxic of NTP zebrafish ( Danio rerio ) embryos early larval stages. Developmental mortality analyses were performed exposed 168 h at concentrations ranging from 500 46,900 µg/L. Locomotor behaviour acetylcholinesterase (AChE) activity by exposing embryos/larvae lower (0.006–500 µg/L). The median lethal concentration after exposure was 2190 Although did not identify significant developmental changes treated groups, lack equilibrium already visible surviving larvae ≥ µg/L NTP. behavioural showed that capable modifying swimming behaviour, even extremely low (0.006 0.088 µg/L) environmentally relevant concentrations. We consistently observed reduction AChE animals Our results highlight acute early-life stages zebrafish. Most importantly, may affect locomotor which turn could reduce fitness species. More studies involving chronic sensitive endpoints warranted better understand effect more realistic scenario. • toxicity nortriptyline investigated h-LC 50 μg/L. Organisms identifiable impairs levels. inhibits activity.
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ژورنال
عنوان ژورنال: Ecotoxicology and Environmental Safety
سال: 2021
ISSN: ['0147-6513', '1090-2414']
DOI: https://doi.org/10.1016/j.ecoenv.2020.111868